FCRL4
Function
May function as an inhibitor of the B-cell receptor signaling. May function in the B-cell-mediated immune response.
Involvement in disease
A chromosomal aberration involving FCRL4 is found in non-Hodgkin lymphoma (NHG). Translocation t(1;1)(p36.3; q21.1-2).
A chromosomal aberration involving FCRL4 is found in multiple myeloma (MM). Translocation t(1;14)(q21;q32) that forms a FCRL4-IGHA1 fusion protein.
Post-translational modifications
Phosphorylated on cytoplasmic tyrosines upon activation.
Tissue Specificity
Specifically expressed by memory and monocytoid B-cells which populate spleen and lymph nodes. Preferentially expressed in memory B-cells associated with mucosal tissue (at protein level).
Cellular localization
- Cell membrane
- Single-pass type I membrane protein
Alternative names
CD307d, FCRH4, IFGP2, IRTA1, FCRL4, Fc receptor-like protein 4, FcR-like protein 4, FcRL4, Fc receptor homolog 4, IFGP family protein 2, Immune receptor translocation-associated protein 1, FcRH4, hIFGP2