Fetuin-B
Function
Protease inhibitor required for egg fertilization. Required to prevent premature zona pellucida hardening before fertilization, probably by inhibiting the protease activity of ASTL, a protease that mediates the cleavage of ZP2 and triggers zona pellucida hardening.
Sequence Similarities
Belongs to the fetuin family.
Tissue Specificity
Liver, lung and tongue.
Cellular localization
- Secreted
Alternative names
Fetuin-B, Fetuin-like protein IRL685, Fetub