Fetuin-B
Developmental stage
2-fold increase toward the end of the menstrual cycle.
Function
Protease inhibitor required for egg fertilization. Required to prevent premature zona pellucida hardening before fertilization, probably by inhibiting the protease activity of ASTL, a protease that mediates the cleavage of ZP2 and triggers zona pellucida hardening (By similarity).
Sequence Similarities
Belongs to the fetuin family.
Tissue Specificity
Liver and testis.
Cellular localization
- Secreted
Alternative names
Fetuin-B, 16G2, Fetuin-like protein IRL685, Gugu, FETUB