Fezf2
Developmental stage
Expressed in the olfactory epithelium, hypothalamus, ventrolateral pallium and prethalamus at mid-gestation. At 12.5 dpc, highly enriched in the postmigratory pyramidal neurons forming the cortical plate situated beneath the pial surface. At 13.5 dpc, expressed in the ventricular zone and subventricular zone at low levels, expression is much higher in the developing cortical plate, where postmitotic neurons are positioned. During late embryonic and early postnatal development, expression disappears from cortical progenitors and becomes restricted to the subplate and the prospective layer V and VI pyramidal neurons.
Function
Transcription repressor. Required for the specification of corticospinal motor neurons and other subcerebral projection neurons. May play a role in layer and neuronal subtype-specific patterning of subcortical projections and axonal fasciculation. Controls the development of dendritic arborization and spines of large layer V pyramidal neurons. Plays a role in rostro-caudal patterning of the diencephalon and in prethalamic formation.
Sequence Similarities
Belongs to the krueppel C2H2-type zinc-finger protein family.
Tissue Specificity
Highly expressed in neocortical layer V, moderately expressed in layer VI. Expressed in subcortically projecting neurons.
Cellular localization
- Nucleus
Alternative names
Fez, Fezl, Zfp312, Fezf2, Fez family zinc finger protein 2, Forebrain embryonic zinc finger-like protein 2, Zinc finger protein 312, Zinc finger protein Fez-like