FGF10
Function
Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing.
Involvement in disease
Aplasia of lacrimal and salivary glands
ALSG
A rare condition characterized by dry conjunctival mucosae, irritable eyes, epiphora (constant tearing), and xerostomia (dryness of the mouth), which increases risk of dental erosion, dental caries, periodontal disease, and oral infections. ALSG has variable expressivity, and affected individuals may have aplasia or hypoplasia of the lacrimal, parotid, submandibular, and sublingual glands and absence of the lacrimal puncta.
None
The disease is caused by variants affecting the gene represented in this entry.
Lacrimo-auriculo-dento-digital syndrome 3
LADD3
A form of lacrimo-auriculo-dento-digital syndrome, an autosomal dominant disease characterized by aplastic/hypoplastic lacrimal and salivary glands and ducts, cup-shaped ears, hearing loss, hypodontia and enamel hypoplasia, and distal limb segments anomalies. In addition to these cardinal features, facial dysmorphism, malformations of the kidney and respiratory system and abnormal genitalia have been reported. Craniosynostosis and severe syndactyly are not observed.
None
The disease is caused by variants affecting the gene represented in this entry.
Sequence Similarities
Belongs to the heparin-binding growth factors family.
Cellular localization
- Secreted
Alternative names
Fibroblast growth factor 10, FGF-10, Keratinocyte growth factor 2, FGF10