FGF19
Function
Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB and FGFR4.
Sequence Similarities
Belongs to the heparin-binding growth factors family.
Tissue Specificity
Expressed in fetal brain, cartilage, retina, and adult gall bladder.
Cellular localization
- Secreted
Alternative names
UNQ334/PRO533, FGF19, Fibroblast growth factor 19, FGF-19