FGF2
GeneName
FGF2
Summary
FGF2, also known as FGF-2 or basic fibroblast growth factor (bFGF), is a 31kDa secreted protein that plays a crucial role in various biological processes, including angiogenesis, cell proliferation, and differentiation. It is expressed in multiple tissues and is found in the cytoplasm, nucleus, and extracellular region. FGF2 functions primarily through its binding to fibroblast growth factor receptors (FGFRs) and has activities such as chemoattractant and cytokine functions. It is involved in processes like endothelial cell proliferation, neuronal development, and organ morphogenesis, contributing to both normal physiological functions and tissue repair mechanisms.
Importance
FGF2 is relevant to: - Angiogenesis and vascular development, making it a target for therapeutic interventions in diseases like cancer and cardiovascular disorders. - Tissue regeneration and repair due to its role in promoting cell migration and proliferation. - Neurodevelopment and neuroprotection, highlighting its potential in neurological research and therapies. - Stem cell biology, as it influences stem cell differentiation and proliferation, which is critical for regenerative medicine.
Top Products
For researchers investigating FGF2, we highly recommend the top-selling recombinant antibody, Anti-FGF2 antibody [EP1735] (ab92337). This antibody has been validated for use in several applications, including Western blotting (WB), immunohistochemistry (IHC), ELISA, and immunoprecipitation (IP), making it a versatile tool for your research needs. With 37 citations, it is well-regarded in the scientific community, reflecting its reliability and effectiveness in FGF2 detection. This product offers the batch-to-batch consistency that is essential for reproducible results in your experiments. The Recombinant human FGF2 protein (Active) ELISA Kit (ab9596), supported by 7 citations, is an excellent option for researchers looking to accurately measure FGF2 levels in their experiments.
Abcam Product Citation Summary
The data indicates that FGF2 is being studied in the context of diabetic wound healing and angiogenic growth factor production using mouse models. Additionally, FGF2 is being measured in the culture medium of human cell lines, suggesting its relevance in various cellular contexts.
Abcam Product Citation Table
Function
Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:8663044). Also acts as an integrin ligand which is required for FGF2 signaling (PubMed:28302677). Binds to integrin ITGAV:ITGB3 (PubMed:28302677). Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration (PubMed:28302677, PubMed:8663044). Functions as a potent mitogen in vitro (PubMed:1721615, PubMed:3732516, PubMed:3964259). Can induce angiogenesis (PubMed:23469107, PubMed:28302677). Mediates phosphorylation of ERK1/2 and thereby promotes retinal lens fiber differentiation (PubMed:29501879).
Post-translational modifications
Phosphorylation at Tyr-215 regulates FGF2 unconventional secretion.
Several N-termini starting at positions 94, 125, 126, 132, 143 and 162 have been identified by direct sequencing.
Sequence Similarities
Belongs to the heparin-binding growth factors family.
Tissue Specificity
Expressed in granulosa and cumulus cells. Expressed in hepatocellular carcinoma cells, but not in non-cancerous liver tissue.
Cellular localization
- Secreted
- Nucleus
- Exported from cells by an endoplasmic reticulum (ER)/Golgi-independent mechanism. Unconventional secretion of FGF2 occurs by direct translocation across the plasma membrane (PubMed:20230531). Binding of exogenous FGF2 to FGFR facilitates endocytosis followed by translocation of FGF2 across endosomal membrane into the cytosol (PubMed:22321063). Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as CEP57 (PubMed:22321063).
Alternative names
FGFB, FGF2, Fibroblast growth factor 2, FGF-2, Basic fibroblast growth factor, Heparin-binding growth factor 2, bFGF, HBGF-2
Database links
swissprot:P09038 omim:134920 entrezGene:2247
Other research areas
- Immuno-oncology