FGF21
GeneName
FGF21
Summary
FGF21, also known as FGF-21 or fibroblast growth factor 21, is a 22 kDa secreted protein that plays a vital role in various physiological processes. It is primarily expressed in the liver, adipose tissue, and skeletal muscle, where it functions in cell-cell signalling and interacts with fibroblast growth factor receptors to activate downstream signalling pathways. FGF21 is involved in the regulation of glucose metabolism, lipid metabolism, and thermogenesis, making it an important factor in energy homeostasis. Additionally, it has been implicated in neurogenesis and the regulation of cell migration.
Importance
FGF21 is relevant to: - Metabolic disorders, including obesity and type 2 diabetes, due to its role in glucose and lipid metabolism - Cold-induced thermogenesis, as it promotes energy expenditure in response to cold exposure - Cardiovascular health through its regulation of low-density lipoprotein clearance - Neurodegenerative diseases, given its involvement in neurogenesis and potential neuroprotective effects
Top Products
For researchers investigating FGF21, we highly recommend the top-selling recombinant antibody, Anti-FGF21 antibody [EPR8314(2)] (ab171941). This antibody has been validated in knockout models, ensuring reliable performance in Western blotting (WB). With 118 citations, it is well-regarded in the research community, reflecting its effectiveness and trustworthiness for FGF21 detection. This product offers the batch-to-batch consistency that is essential for reproducible results in your experiments. "The Human FGF21 ELISA Kit (ab222506), supported by 10 citations, is an excellent option for researchers looking to accurately measure FGF21 levels in their samples."
Abcam Product Citation Summary
The data indicates that FGF21 is being studied in various contexts, particularly in relation to cardiac myocyte responses and adipokine expression. The use of Abcam antibody ab171941 in Western blotting across different species, including mouse and human, highlights its relevance in understanding metabolic and cardiac conditions.
Abcam Product Citation Table
Function
Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity requires the presence of KLB. Regulates systemic glucose homeostasis and insulin sensitivity.
Sequence Similarities
Belongs to the heparin-binding growth factors family.
Cellular localization
- Secreted
Alternative names
UNQ3115/PRO10196, FGF21, Fibroblast growth factor 21, FGF-21