FGF21
Function
Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity requires the presence of KLB. Regulates systemic glucose homeostasis and insulin sensitivity.
Sequence Similarities
Belongs to the heparin-binding growth factors family.
Cellular localization
- Secreted
Alternative names
UNQ3115/PRO10196, FGF21, Fibroblast growth factor 21, FGF-21