FGF5
Developmental stage
Can transform NIH 3T3 cells.
Function
Plays an important role in the regulation of cell proliferation and cell differentiation. Required for normal regulation of the hair growth cycle. Functions as an inhibitor of hair elongation by promoting progression from anagen, the growth phase of the hair follicle, into catagen the apoptosis-induced regression phase (By similarity).
Involvement in disease
Trichomegaly
TCMGLY
A morphologic trait characterized by unusually long eyelashes and mild hypertrichosis of eyebrows. It can be observed in association with corneal irritation, cataracts, and hereditary spherocytosis.
None
The disease is caused by variants affecting the gene represented in this entry.
Sequence Similarities
Belongs to the heparin-binding growth factors family.
Tissue Specificity
Expressed in neonatal brain.
Cellular localization
- Secreted
Alternative names
Fibroblast growth factor 5, FGF-5, Heparin-binding growth factor 5, Smag-82, HBGF-5, FGF5