FGF5

Developmental stage

Can transform NIH 3T3 cells.

Function

Plays an important role in the regulation of cell proliferation and cell differentiation. Required for normal regulation of the hair growth cycle. Functions as an inhibitor of hair elongation by promoting progression from anagen, the growth phase of the hair follicle, into catagen the apoptosis-induced regression phase (By similarity).

Involvement in disease

Trichomegaly

TCMGLY

A morphologic trait characterized by unusually long eyelashes and mild hypertrichosis of eyebrows. It can be observed in association with corneal irritation, cataracts, and hereditary spherocytosis.

None

The disease is caused by variants affecting the gene represented in this entry.

Sequence similarities

Belongs to the heparin-binding growth factors family.

Tissue specificity

Expressed in neonatal brain.

Cellular localization

• Secreted

Alternative names

• Fibroblast growth factor 5
• FGF-5
• Heparin-binding growth factor 5
• Smag-82
• HBGF-5
• FGF5

Database links

• entrezGene:2250
• omim:165190
• swissprot:P12034

Target type

Proteins

Primary research area

Oncology

Molecular weight

29551Da