KGF/FGF-7

Function

Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. Growth factor active on keratinocytes. Possible major paracrine effector of normal epithelial cell proliferation.

Sequence similarities

Belongs to the heparin-binding growth factors family.

Tissue specificity

Epithelial cell.

Cellular localization

• Secreted

Alternative names

• Fibroblast growth factor 7
• FGF-7
• Heparin-binding growth factor 7
• Keratinocyte growth factor
• HBGF-7
• KGF
• FGF7

Database links

• entrezGene:2252
• omim:148180
• swissprot:P21781

Target type

Proteins

Primary research area

Oncology

Molecular weight

22509Da