Fgf8
Function
Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Plays a role in neurite outgrowth in hippocampal cells (By similarity). Cooperates with Wnt-1 in mouse mammary tumor virus-induced murine mammary tumorigenesis (PubMed:7884899).
Post-translational modifications
The N-terminus is blocked.
Sequence Similarities
Belongs to the heparin-binding growth factors family.
Tissue Specificity
Absent in normal mammary glands and detected only in adult testis and ovary and in midgestational embryos.
Cellular localization
- Secreted
Alternative names
Aigf, Fgf8, Fibroblast growth factor 8, FGF-8, Androgen-induced growth factor, Heparin-binding growth factor 8, AIGF, HBGF-8