FGFR1OP2
Function
May be involved in wound healing pathway.
Involvement in disease
A chromosomal aberration involving FGFR1OP2 may be a cause of stem cell myeloproliferative disorder (MPD). Insertion ins(12;8)(p11;p11p22) with FGFR1. MPD is characterized by myeloid hyperplasia, eosinophilia and T-cell or B-cell lymphoblastic lymphoma. In general it progresses to acute myeloid leukemia. The fusion protein FGFR1OP2-FGFR1 may exhibit constitutive kinase activity and be responsible for the transforming activity.
Sequence Similarities
Belongs to the SIKE family.
Tissue Specificity
Expressed in bone marrow, spleen and thymus.
Cellular localization
- Cytoplasm
Alternative names
HSPC123, FGFR1OP2, FGFR1 oncogene partner 2