FHL2
Domain
The third LIM zinc-binding mediates interaction with E4F1.
Function
May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation. Negatively regulates the calcineurin/NFAT signaling pathway in cardiomyocytes (PubMed:28717008).
Tissue Specificity
Expressed in skeletal muscle and heart.
Cellular localization
- Cytoplasm
- Nucleus
- Cytoplasm
- Myofibril
- Sarcomere
- Z line
Alternative names
DRAL, SLIM3, FHL2, Four and a half LIM domains protein 2, FHL-2, LIM domain protein DRAL, Skeletal muscle LIM-protein 3, SLIM-3