FHL2

The third LIM zinc-binding mediates interaction with E4F1.

May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation. Negatively regulates the calcineurin/NFAT signaling pathway in cardiomyocytes (PubMed:28717008).

Expressed in skeletal muscle and heart.

• Cytoplasm
• Nucleus
• Cytoplasm
• Myofibril
• Sarcomere
• Z line

DRAL, SLIM3, FHL2, Four and a half LIM domains protein 2, FHL-2, LIM domain protein DRAL, Skeletal muscle LIM-protein 3, SLIM-3

• entrezGene:2274
• omim:602633
• swissprot:Q14192

Proteins

Metabolism

32193Da