Fibroblast growth factor 16
Function
Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation, and is required for normal cardiomyocyte proliferation and heart development.
Involvement in disease
Metacarpal 4-5 fusion
MF4
A rare congenital malformation of the hand characterized by the partial or complete fusion of the fourth and fifth metacarpals. The anomaly occurs as an isolated trait or part of a syndrome.
None
The disease is caused by variants affecting the gene represented in this entry.
Sequence Similarities
Belongs to the heparin-binding growth factors family.
Cellular localization
- Secreted
Alternative names
Fibroblast growth factor 16, FGF-16, FGF16