FIGNL1
Domain
The N-terminus is necessary for its recruitment to DNA damage sites.
Function
Involved in DNA double-strand break (DBS) repair via homologous recombination (HR). Recruited at DSB sites independently of BRCA2, RAD51 and RAD51 paralogs in a H2AX-dependent manner. May regulate osteoblast proliferation and differentiation (PubMed:23754376). May play a role in the control of male meiosis dynamic (By similarity).
Sequence Similarities
Belongs to the AAA ATPase family.
Cellular localization
- Nucleus
- Cytoplasm
- Cytoplasm
- Perinuclear region
- Together with RAD51 and a subset of H2A histone proteins, redistributed in discrete nuclear DNA damage-induced foci after ionizing radiation (IR) treatment (PubMed:23754376).
Alternative names
Fidgetin-like protein 1, FIGNL1