FIRRM
Function
Regulates PLK1 kinase activity at kinetochores and promotes faithful chromosome segregation in prometaphase by bridging kinase and phosphatase activities (PubMed:34260926). Phosphorylation of FIRRM by PLK1 negatively regulates its interaction with the phosphatase, PPP1CC, thus creating a negative feedback loop for maintaining proper PLK1 kinase activity during mitosis (PubMed:34260926). In complex with FIGL1 may regulate homologous recombination (PubMed:29608566).
Post-translational modifications
Phosphorylation at Ser-43 by PLK1 strengthens FIRRM-PLK1 interaction (PubMed:34260926). Phosphorylation at Ser-744 by PLK1 negatively regulates its interaction with PPP1CC (PubMed:34260926).
Cellular localization
- Chromosome
- Centromere
- Kinetochore
- Nucleus
- Chromosome
- Centromere
- Midbody
- Cytoplasm
- Cytoskeleton
- Spindle
- Exhibits cell-cycle-dependent distribution during mitosis. Detected in the nucleus in interphase. Colocalizes with PLK1 to the centromeres in a nearby prometaphase cells. Relocates to the central spindle in anaphase and to the midbody in telophase cells.
Alternative names
APOLO1, C1orf112, FIRRM, FIGNL1-interacting regulator of recombination and mitosis, FIDGETIN-like-1 interacting protein, POLO1-associating protein, FLIP