FKBP15

Domain

The PPIase FKBP-type domain seems to be inactive both for FK506-binding and enzymatic activity.

The central coiled-coil region is responsible for association with early endosomes.

Function

May be involved in the cytoskeletal organization of neuronal growth cones. Seems to be inactive as a PPIase (By similarity). Involved in the transport of early endosomes at the level of transition between microfilament-based and microtubule-based movement.

Sequence Similarities

Belongs to the FKBP-type PPIase family.

Cellular localization

• Cytoplasm
• Cell projection
• Axon
• Early endosome
• Present in axons and neuronal growth cones.

Alternative names

KIAA0674, FKBP15, FK506-binding protein 15, FKBP-15, 133 kDa FK506-binding protein, WASP- and FKBP-like protein, 133 kDa FKBP, FKBP-133, WAFL

Database links

swissprot:Q5T1M5 swissprot:Q6DD85 swissprot:Q9Y4D0 swissprot:Q5T1M2 entrezGene:23307