FKBP1A

Function

Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruits SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

Sequence similarities

Belongs to the FKBP-type PPIase family. FKBP1 subfamily.

Cellular localization

• Cytoplasm
• Cytosol
• Sarcoplasmic reticulum membrane
• Peripheral membrane protein
• Cytoplasmic side

Alternative names

• Peptidyl-prolyl cis-trans isomerase FKBP1A
• PPIase FKBP1A
• 12 kDa FK506-binding protein
• Calstabin-1
• FK506-binding protein 1A
• Immunophilin FKBP12
• Rotamase
• 12 kDa FKBP
• FKBP-12
• FKBP-1A
• FKBP1A
• FKBP12
• FKBP1

Database links

• entrezGene:2280
• omim:186945
• swissprot:P62942

Target type

Proteins

Molecular weight

11951Da