FKBP1B
Function
Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Sequence Similarities
Belongs to the FKBP-type PPIase family. FKBP1 subfamily.
Tissue Specificity
Detected in heart muscle (at protein level). Isoform 1 and isoform 2 are ubiquitous with highest levels in brain and thymus.
Cellular localization
- Cytoplasm
- Sarcoplasmic reticulum
Alternative names
FKBP12.6, FKBP1L, FKBP9, OTK4, FKBP1B, Peptidyl-prolyl cis-trans isomerase FKBP1B, PPIase FKBP1B, 12.6 kDa FK506-binding protein, FK506-binding protein 1B, Immunophilin FKBP12.6, Rotamase, h-FKBP-12, 12.6 kDa FKBP, FKBP-12.6, FKBP-1B