FKBP25

Function

FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. PPIases accelerate the folding of proteins.

Sequence similarities

Belongs to the FKBP-type PPIase family.

Cellular localization

• Nucleus

Alternative names

• FKBP25
• FKBP3
• FKBP25
• Peptidyl-prolyl cis-trans isomerase FKBP3
• PPIase FKBP3
• 25 kDa FK506-binding protein
• FK506-binding protein 3
• Immunophilin FKBP25
• Rapamycin-selective 25 kDa immunophilin
• Rotamase
• 25 kDa FKBP
• FKBP-25
• FKBP-3

Database links

• entrezGene:2287
• omim:186947
• swissprot:Q00688

Target type

Proteins

Molecular weight

25177Da