FLRT2
Function
Functions in cell-cell adhesion, cell migration and axon guidance. Mediates cell-cell adhesion via its interactions with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells. May play a role in the migration of cortical neurons during brain development via its interaction with UNC5D. Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5D, and possibly also other UNC-5 family members. Plays a role in fibroblast growth factor-mediated signaling cascades. Required for normal organization of the cardiac basement membrane during embryogenesis, and for normal embryonic epicardium and heart morphogenesis.
Post-translational modifications
N-glycosylated.
Proteolytic cleavage in the juxtamembrane region gives rise to a soluble ectodomain. Cleavage is probably effected by a metalloprotease.
Tissue Specificity
Expressed in pancreas, skeletal muscle, brain, and heart.
Cellular localization
- Cell membrane
- Single-pass membrane protein
- Endoplasmic reticulum membrane
- Cell junction
- Focal adhesion
- Secreted
- Extracellular space
- Extracellular matrix
- Microsome membrane
- Secreted
- Synapse
- Synaptosome
- Proteolytic cleavage gives rise to a shedded ectodomain.
Alternative names
KIAA0405, UNQ232/PRO265, FLRT2, Leucine-rich repeat transmembrane protein FLRT2, Fibronectin-like domain-containing leucine-rich transmembrane protein 2