FMNL2
Domain
The DAD domain regulates activation via by an autoinhibitory interaction with the GBD/FH3 domain. This autoinhibition is released upon competitive binding of an activated GTPase. The release of DAD allows the FH2 domain to then nucleate and elongate nonbranched actin filaments (By similarity).
Function
Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics.
Sequence Similarities
Belongs to the formin homology family.
Cellular localization
- Cytoplasm
Alternative names
FHOD2, KIAA1902, FMNL2, Formin-like protein 2, Formin homology 2 domain-containing protein 2