FMNL3
Domain
The DAD domain regulates activation via by an autoinhibitory interaction with the GBD/FH3 domain. This autoinhibition is released upon competitive binding of an activated GTPase. The release of DAD allows the FH2 domain to then nucleate and elongate nonbranched actin filaments (By similarity).
Function
Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. Required for developmental angiogenesis (By similarity). In this process, required for microtubule reorganization and for efficient endothelial cell elongation. In quiescent endothelial cells, triggers rearrangement of the actin cytoskeleton, but does not alter microtubule alignement.
Sequence Similarities
Belongs to the formin homology family.
Tissue Specificity
Expressed in endothelial cells.
Cellular localization
- Cytoplasm
- Cell membrane
- Lipid-anchor
- Enriched in lamellipodia.
Alternative names
FHOD3, FRL2, KIAA2014, WBP3, FMNL3, Formin-like protein 3, Formin homology 2 domain-containing protein 3, WW domain-binding protein 3, WBP-3