FN3K
Function
Fructosamine-3-kinase involved in protein deglycation by mediating phosphorylation of fructoselysine residues on glycated proteins, to generate fructoselysine-3 phosphate (PubMed:11016445, PubMed:11522682, PubMed:11975663). Fructoselysine-3 phosphate adducts are unstable and decompose under physiological conditions (PubMed:11522682, PubMed:11975663). Involved in intracellular deglycation in erythrocytes (PubMed:11975663). Involved in the response to oxidative stress by mediating deglycation of NFE2L2/NRF2, glycation impairing NFE2L2/NRF2 function (By similarity). Also able to phosphorylate psicosamines and ribulosamines (PubMed:14633848).
Sequence Similarities
Belongs to the fructosamine kinase family.
Tissue Specificity
Widely expressed (PubMed:11522682). Expressed in erythrocytes (PubMed:11016445).
Alternative names
Fructosamine-3-kinase, Protein-psicosamine 3-kinase FN3K, Protein-ribulosamine 3-kinase FN3K, FN3K