FNDC4

Function

Soluble FNDC4

Has anti-inflammatory properties. In the colon, acts on macrophages to down-regulate inflammation. May suppress osteoclastogenesis and mature osteoclast resorptive function. In white adipose tissue, decreases local inflammation, via interaction with GPR116. Also required for proper systemic glucose tolerance, specifically sensitizing white adipocytes to insulin and promoting glucose uptake. The insulin sensitizing function in adipose tissue is mediated by interaction with ADGRF5/GPR116 and activation of cAMP signaling.

Tissue Specificity

Highly expressed in the liver and the brain, including in the cortex, hypothalamus and hippocampus (PubMed:34016966). Also expressed in adipose tissue (PubMed:34016966).

Cellular localization

• Fibronectin type III domain-containing protein 4
• Membrane
• Single-pass type I membrane protein
• Soluble FNDC4
• Secreted

Alternative names

FRCP1, UNQ6389/PRO21134, FNDC4, Fibronectin type III domain-containing protein 4, Fibronectin type III repeat-containing protein 1

Database links

swissprot:Q9H6D8 entrezGene:64838 omim:611905 genbank:NP_073734.1