FNDC5
Domain
Fibronectin type-III domain is capable of forming a continuous intersubunit beta-sheet dimer; dimerization may thereby play a role in cell-cell adhesion or signaling.
Function
Irisin
Contrary to mouse, may not be involved in the beneficial effects of muscular exercise, nor in the induction of browning of human white adipose tissue.
Post-translational modifications
The extracellular domain is cleaved and released from the cell membrane.
N-Glycosylated.
Tissue Specificity
Widely expressed, with highest levels in heart. Very low expression, if any, in colon, pancreas and spleen.
Cellular localization
- Cell membrane
- Single-pass type I membrane protein
- Peroxisome membrane
- Single-pass type I membrane protein
- Imported in peroxisomes through the PEX5 receptor pathway.
- Irisin
- Secreted
- Detected in the blood of individuals subjected to endurance exercise.
Alternative names
FRCP2, FNDC5, Fibronectin type III domain-containing protein 5, Fibronectin type III repeat-containing protein 2