Fndc5
Developmental stage
During embryonic development, it is detected almost exclusively in the skeletal muscle, and at lower level in brain. In skeletal muscle, it is induced after myoblast differentiation, when myotube formation is promoted.
Domain
Fibronectin type-III domain is capable of forming a continuous intersubunit beta-sheet dimer; dimerization may thereby play a role in cell-cell adhesion or signaling.
Function
Irisin
Mediates beneficial effects of muscular exercise. Induces browning of white adipose tissue by stimulating UCP1 expression, at least in part, via the nuclear receptor PPARA.
Post-translational modifications
The extracellular domain is cleaved and released from the cell membrane.
N-Glycosylated.
Tissue Specificity
In adult, it is highly expressed in skeletal muscle, heart and brain.
Cellular localization
- Cell membrane
- Single-pass type I membrane protein
- Peroxisome membrane
- Single-pass type I membrane protein
- Secreted
- Imported in peroxisomes through the PEX5 receptor pathway.
- Irisin
- Secreted
- Detected in the blood of individuals subjected to endurance exercise.
Alternative names
Frcp2, Pep, Fndc5, Fibronectin type III domain-containing protein 5, Fibronectin type III repeat-containing protein 2, Peroxisomal protein, PeP