Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release.
N-glycosylated.
Belongs to the folate receptor family.
Expressed in placenta and hematopoietic cells. Expression is increased in malignant tissues.
Folate receptor beta, FR-beta, Folate receptor 2, Placental folate-binding protein, FBP, FOLR2
Proteins
Immunology & Infectious Disease
29280Da
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