FOLR2
Function
Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release.
Post-translational modifications
N-glycosylated.
Sequence Similarities
Belongs to the folate receptor family.
Tissue Specificity
Expressed in placenta and hematopoietic cells. Expression is increased in malignant tissues.
Cellular localization
- Cell membrane
- Lipid-anchor
- GPI-anchor
- Secreted
Alternative names
Folate receptor beta, FR-beta, Folate receptor 2, Placental folate-binding protein, FBP, FOLR2