Folr2
Function
Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release (By similarity).
Sequence Similarities
Belongs to the folate receptor family.
Cellular localization
- Cell membrane
- Lipid-anchor
- GPI-anchor
Alternative names
Fbp2, Folbp2, Folr2, Folate receptor beta, FR-beta, Folate receptor 2, Folate-binding protein 2