FOSL2
Function
Controls osteoclast survival and size (By similarity). As a dimer with JUN, activates LIF transcription (By similarity). Activates CEBPB transcription in PGE2-activated osteoblasts (By similarity).
Involvement in disease
Aplasia cutis-enamel dysplasia
ACED
An autosomal dominant disorder characterized by congenital absence of a portion of skin of the scalp with or without skull defects, enamel hypoplasia, and neurodevelopmental delay with autism spectrum disorder.
None
The disease is caused by variants affecting the gene represented in this entry.
Sequence Similarities
Belongs to the bZIP family. Fos subfamily.
Cellular localization
- Nucleus
Alternative names
FRA2, FOSL2, Fos-related antigen 2, FRA-2