FOXH1

Domain

The FM region is required for binding SMAD2/SMAD4 complexes. FM2 is more effective than FM1 and only interacts with phosphorylated SMAD2 that is in an activated SMAD complex (By similarity).

Function

Transcriptional activator. Recognizes and binds to the DNA sequence 5'-TGT[GT][GT]ATT-3'. Required for induction of the goosecoid (GSC) promoter by TGF-beta or activin signaling. Forms a transcriptionally active complex containing FOXH1/SMAD2/SMAD4 on a site on the GSC promoter called TARE (TGF-beta/activin response element).

Tissue specificity

Ubiquitous.

Cellular localization

• Nucleus

Alternative names

• Forkhead box protein H1
• Forkhead activin signal transducer 1
• Forkhead activin signal transducer 2
• Fast-1
• hFAST-1
• Fast-2
• FOXH1
• FAST1
• FAST2

Database links

• entrezGene:8928
• omim:603621
• swissprot:O75593

Target type

Proteins

Molecular weight

39257Da