FOXH1
Domain
The FM region is required for binding SMAD2/SMAD4 complexes. FM2 is more effective than FM1 and only interacts with phosphorylated SMAD2 that is in an activated SMAD complex (By similarity).
Function
Transcriptional activator. Recognizes and binds to the DNA sequence 5'-TGT[GT][GT]ATT-3'. Required for induction of the goosecoid (GSC) promoter by TGF-beta or activin signaling. Forms a transcriptionally active complex containing FOXH1/SMAD2/SMAD4 on a site on the GSC promoter called TARE (TGF-beta/activin response element).
Tissue Specificity
Ubiquitous.
Cellular localization
- Nucleus
Alternative names
FAST1, FAST2, FOXH1, Forkhead box protein H1, Forkhead activin signal transducer 1, Forkhead activin signal transducer 2, Fast-1, hFAST-1, Fast-2