FPGS
Function
Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis. Unsubstituted reduced folates are the preferred substrates. Metabolizes methotrexate (MTX) to polyglutamates.
Pathway
Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis.
Sequence Similarities
Belongs to the folylpolyglutamate synthase family.
Cellular localization
- Isoform 1
- Mitochondrion inner membrane
- Mitochondrion matrix
- Isoform 2
- Cytoplasm
Alternative names
Folylpoly-gamma-glutamate synthetase, Tetrahydrofolylpolyglutamate synthase, FPGS, Tetrahydrofolate synthase