FPR3
Function
Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Acts as a receptor for humanin (PubMed:15465011).
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family.
Tissue Specificity
Detected in various tissues with highest expression in lung.
Cellular localization
- Cell membrane
- Multi-pass membrane protein
Alternative names
FPRH1, FPRL2, FPR3, N-formyl peptide receptor 3, FMLP-related receptor II, Formyl peptide receptor-like 2, FMLP-R-II