Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Acts as a receptor for humanin (PubMed:15465011).
Belongs to the G-protein coupled receptor 1 family.
Detected in various tissues with highest expression in lung.
FPRH1, FPRL2, FPR3, N-formyl peptide receptor 3, FMLP-related receptor II, Formyl peptide receptor-like 2, FMLP-R-II
Proteins
Immunology & Infectious Disease
39965Da
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ab150568
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