FRAT1
Function
Positively regulates the Wnt signaling pathway by stabilizing beta-catenin through the association with GSK-3. May play a role in tumor progression and collaborate with PIM1 and MYC in lymphomagenesis.
Post-translational modifications
Phosphorylated.
Sequence Similarities
Belongs to the GSK-3-binding protein family.
Cellular localization
- Cytoplasm
Alternative names
Proto-oncogene FRAT1, Frequently rearranged in advanced T-cell lymphomas 1, FRAT-1, FRAT1