Frizzled-5
Developmental stage
Detected at low levels in neonate brain; expression levels increase steadily during the first four weeks after birth and show a further increase in adults (at protein level) (PubMed:20530549). Expressed in the yolk sac, placenta, eye and lung bud at 9.5 dpc. At 10.5 dpc, also expressed in the placental blood vessel of embryonic origin (PubMed:11092808).
Domain
The PDZ-binding motif mediates interaction with GOPC.
The FZ domain is involved in binding with Wnt ligands.
Function
Receptor for Wnt proteins (PubMed:11092808, PubMed:18230341). Functions in the canonical Wnt/beta-catenin signaling pathway (PubMed:18230341). In vitro activates WNT2, WNT10B, WNT5A, but not WNT2B or WNT4 signaling (PubMed:11092808). In neurons, activation by WNT7A promotes formation of synapses (By similarity). May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable). Plays a role in yolk sac angiogenesis and in placental vascularization (PubMed:11092808). Plays a role in ocular development (By similarity).
Post-translational modifications
Ubiquitinated by RNF43 and ZNRF3, leading to its degradation by the proteasome.
Sequence Similarities
Belongs to the G-protein coupled receptor Fz/Smo family.
Tissue Specificity
Detected in hippocampus (at protein level) (PubMed:20530549). Expressed in eye, kidney, lung, chondrocytes, epithelial cells of the small intestine and gobelet cells of the colon (PubMed:8626800).
Cellular localization
- Cell membrane
- Multi-pass membrane protein
- Golgi apparatus membrane
- Multi-pass membrane protein
- Synapse
- Perikaryon
- Cell projection
- Dendrite
- Cell projection
- Axon
- Localized at the plasma membrane and also found at the Golgi apparatus.
Alternative names
Frizzled-5, Fz-5, mFz5, Fzd5