FRK
Function
Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor.
Sequence Similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
Tissue Specificity
Predominantly expressed in epithelial derived cell lines and tissues, especially normal liver, kidney, breast and colon.
Cellular localization
- Cytoplasm
- Nucleus
- Predominantly found in the nucleus, with a small fraction found in the cell periphery.
Alternative names
PTK5, RAK, FRK, Tyrosine-protein kinase FRK, FYN-related kinase, Nuclear tyrosine protein kinase RAK, Protein-tyrosine kinase 5