FRYL
Function
Plays a key role in maintaining the integrity of polarized cell extensions during morphogenesis, regulates the actin cytoskeleton and plays a key role in patterning sensory neuron dendritic fields by promoting avoidance between homologous dendrites as well as by limiting dendritic branching (By similarity). May function as a transcriptional activator.
Involvement in disease
A chromosomal aberration involving FRYL is found in treatment-related acute lymphoblastic leukemia (ALL). Translocation t(4;11)(p12;q23) that forms a KMT2A/MLL1-FRYL fusion protein.
Sequence Similarities
Belongs to the furry protein family.
Tissue Specificity
Widely expressed with higher expression in colon, placenta, brain and cells of lymphoid origin.
Alternative names
AF4P12, KIAA0826, FRYL, Protein furry homolog-like, ALL1-fused gene from chromosome 4p12 protein