Frzb
Developmental stage
In early gastrulation, expressed in all three germ layers. In later embryogenesis, expressed in a range of tissues including the central and peripheral nervous systems and the nephogenic mesenchyme.
Domain
The FZ domain is involved in binding with Wnt ligands.
Function
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development (By similarity).
Sequence Similarities
Belongs to the secreted frizzled-related protein (sFRP) family.
Tissue Specificity
Expressed in kidney, brain, testis. Weak expression in spleen and heart.
Cellular localization
- Secreted
Alternative names
Fiz, Fre, Frzb1, Sfrp3, Frzb, Secreted frizzled-related protein 3, sFRP-3, Frezzled, Fritz, Frizzled-related protein 1, FrzB-1