FSCN1
Domain
Composed of four fascin beta-trefoil domains.
Function
Actin-binding protein that contains 2 major actin binding sites (PubMed:21685497, PubMed:23184945). Organizes filamentous actin into parallel bundles (PubMed:20393565, PubMed:21685497, PubMed:23184945). Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers (PubMed:22155786). Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration (PubMed:20393565, PubMed:21685497, PubMed:23184945). Mediates reorganization of the actin cytoskeleton and axon growth cone collapse in response to NGF (PubMed:22155786).
Post-translational modifications
Phosphorylation at Ser-39 inhibits actin-binding (PubMed:8647875, PubMed:8999969). Phosphorylation is required for the reorganization of the actin cytoskeleton in response to NGF (PubMed:22155786).
Sequence Similarities
Belongs to the fascin family.
Tissue Specificity
Ubiquitous.
Cellular localization
- Cytoplasm
- Cytosol
- Cytoplasm
- Cell cortex
- Cytoplasm
- Cytoskeleton
- Cytoplasm
- Cytoskeleton
- Stress fiber
- Cell projection
- Filopodium
- Cell projection
- Invadopodium
- Cell projection
- Microvillus
- Cell junction
- Colocalized with RUFY3 and F-actin at filipodia of the axonal growth cone. Colocalized with DBN1 and F-actin at the transitional domain of the axonal growth cone (By similarity).
Alternative names
FAN1, HSN, SNL, FSCN1, Fascin, 55 kDa actin-bundling protein, Singed-like protein, p55