Fascin

Composed of four fascin beta-trefoil domains.

Actin-binding protein that contains 2 major actin binding sites (PubMed:21685497, PubMed:23184945). Organizes filamentous actin into parallel bundles (PubMed:20393565, PubMed:21685497, PubMed:23184945). Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers (PubMed:22155786). Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration (PubMed:20393565, PubMed:21685497, PubMed:23184945). Mediates reorganization of the actin cytoskeleton and axon growth cone collapse in response to NGF (PubMed:22155786).

Phosphorylation at Ser-39 inhibits actin-binding (PubMed:8647875, PubMed:8999969). Phosphorylation is required for the reorganization of the actin cytoskeleton in response to NGF (PubMed:22155786).

Belongs to the fascin family.

Ubiquitous.

• Cytoplasm
• Cytosol
• Cytoplasm
• Cell cortex
• Cytoplasm
• Cytoskeleton
• Cytoplasm
• Cytoskeleton
• Stress fiber
• Cell projection
• Filopodium
• Cell projection
• Invadopodium
• Cell projection
• Microvillus
• Cell junction
• Colocalized with RUFY3 and F-actin at filipodia of the axonal growth cone. Colocalized with DBN1 and F-actin at the transitional domain of the axonal growth cone (By similarity).

FAN1, HSN, SNL, FSCN1, Fascin, 55 kDa actin-bundling protein, Singed-like protein, p55

• entrezGene:6624
• omim:602689
• swissprot:Q16658

Proteins

Oncology

54530Da