FSD1
Domain
B30.2 box contains a microtubule-binding site.
Function
May be involved in microtubule organization and stabilization.
Tissue Specificity
Highly expressed in brain tissues, including cerebellum, cerebral cortex, medulla, occipital pole, frontal lobe, temporal lobe and putamen. Lower expression in spinal chord.
Cellular localization
- Cytoplasm
- Cytoskeleton
- Microtubule organizing center
- Centrosome
- Nucleus
- Cytoplasm
- Cleavage furrow
- Cell-cycle-dependent association with the centrosome. Colocalizes with a subpopulation of microtubules. Does not associate with microtubules during mitosis but reassociates with microtubules during cytokinesis. Localizes to the central portions of a small subset of microtubules in interphase cells and a subpopulation of microtubules in the cleavage furrow, not present in the mitotic spindle.
Alternative names
GLFND, MIR1, VLP27, FSD1, Fibronectin type III and SPRY domain-containing protein 1, MID1-related protein 1, Microtubule-associated protein GLFND