FSHB
Function
Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways. Follitropin is involved in follicle development and spermatogenesis in reproductive organs.
Sequence Similarities
Belongs to the glycoprotein hormones subunit beta family.
Cellular localization
- Secreted
- Efficient secretion requires dimerization with CGA.
Alternative names
Follitropin subunit beta, Follicle-stimulating hormone beta subunit, Follitropin beta chain, FSH-B, FSH-beta, FSHB