FST

Function

Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH).

Tissue Specificity

Isoform 1 is the predominant isoform in serum but is undetectable in follicular fluid. In the embryo, strong expression is seen in the palatal epithelia, including the medial edge epithelial and midline epithelial seam of the palatal shelves. Less pronounced expression is also seen throughout the palatal shelf and tongue mesenchyme (PubMed:31215115).

Cellular localization

• Secreted

Alternative names

Follistatin, FS, Activin-binding protein, FST

Database links

swissprot:P19883 omim:136470 entrezGene:10468

Other research areas

• Cardiovascular