FSTL1
Function
Secreted glycoprotein that is involved in various physiological processes, such as angiogenesis, regulation of the immune response, cell proliferation and differentiation (PubMed:22265692, PubMed:29212066). Plays a role in the development of the central nervous system, skeletal system, lungs, and ureter (By similarity). Promotes endothelial cell survival, migration and differentiation into network structures in an AKT-dependent manner. Also promotes survival of cardiac myocytes (By similarity). Initiates various signaling cascades by activating different receptors on the cell surface such as DIP2A, TLR4 or BMP receptors (PubMed:20054002, PubMed:22265692).
Tissue Specificity
Overexpressed in synovial tissues from rheumatoid arthritis (PubMed:15638044).
Cellular localization
- Secreted
Alternative names
FRP, FSTL1, Follistatin-related protein 1, Follistatin-like protein 1