Fstl1
Function
Secreted glycoprotein that is involved in various physiological processes, such as angiogenesis, regulation of the immune response, cell proliferation and differentiation (By similarity). Plays a role in the development of the central nervous system, skeletal system, lungs, and ureter (PubMed:19595790, PubMed:21826198). Promotes endothelial cell survival, migration and differentiation into network structures in an AKT-dependent manner. Also promotes survival of cardiac myocytes (PubMed:20054002). Initiates various signaling cascades by activating different receptors on the cell surface such as DIP2A, TLR4 or BMP receptors (By similarity).
Tissue Specificity
During central nervous system development, strongly expressed in the telencephalon, diencephalon, brainstem, limbic system and spinal cord (PubMed:19595790). Widely expressed in all organs (PubMed:21826198).
Cellular localization
- Secreted
Alternative names
Frp, Fstl, Tsc36, Fstl1, Follistatin-related protein 1, Follistatin-like protein 1, TGF-beta-inducible protein TSC-36