Ftl1
Function
Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney. Degraded to release iron upon autophagy activation by nutrient starvation (PubMed:25327288).
Sequence Similarities
Belongs to the ferritin family.
Cellular localization
- Cytoplasm
- Cytoplasmic vesicle
- Autophagosome
- Autolysosome
Alternative names
Ftl, Ftl-1, Ftl1, Ferritin light chain 1, Ferritin L subunit 1