Ftl1

The rat light chain has an octopeptide insertion after residue 158 compared with other light chains.

Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). Delivery to lysosomes by the cargo receptor NCOA4 for autophagic degradation and release or iron (By similarity).

Belongs to the ferritin family.

In rat liver, the light chain is the major chain.

• Cytoplasmic vesicle
• Autophagosome
• Cytoplasm
• Autolysosome

Ftl, Ftl1, Ferritin light chain 1, Ferritin L subunit 1

• swissprot:P02793

Proteins