FUNDC2
Function
Binds directly and specifically 1,2-Diacyl-sn-glycero-3-phospho-(1'-myo-inositol-3',4',5'-bisphosphate) (PIP3) leading to the recruitment of PIP3 to mitochondria and may play a role in the regulation of the platelet activation via AKT/GSK3B/cGMP signaling pathways (PubMed:29786068). May act as transcription factor that regulates SREBP1 (isoform SREBP-1C) expression in order to modulate triglyceride (TG) homeostasis in hepatocytes (PubMed:25855506, PubMed:29187281).
Sequence Similarities
Belongs to the FUN14 family.
Tissue Specificity
Highly expressed in platelets (at protein level).
Cellular localization
- Mitochondrion outer membrane
- Multi-pass membrane protein
- Nucleus
Alternative names
HCBP6, DC44, HCC3, PD03104, FUNDC2, FUN14 domain-containing protein 2, Cervical cancer proto-oncogene 3 protein, Hepatitis C virus core-binding protein 6, HCC-3