Galactoside 2-alpha-L-fucosyltransferase 1

Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the terminal galactose residue of glycoconjugates through an alpha(1,2) linkage leading to H antigen synthesis that is an intermediate substrate in the synthesis of ABO blood group antigens (PubMed:2118655). H antigen is essential for maturation of the glomerular layer of the main olfactory bulb, in cell migration and early cell-cell contacts during tumor associated angiogenesis (PubMed:18205178). Preferentially fucosylates soluble lactose and to a lesser extent fucosylates glycolipids gangliosides GA1 and GM1a (By similarity).

Protein modification; protein glycosylation.

Belongs to the glycosyltransferase 11 family.

• Golgi apparatus
• Golgi stack membrane
• Single-pass type II membrane protein
• Membrane-bound form in trans cisternae of Golgi.

H, HSC, FUT1, Blood group H alpha 2-fucosyltransferase, Fucosyltransferase 1, GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 1

• entrezGene:2523
• omim:211100
• swissprot:P19526

Proteins

Immunology & Infectious Disease

41251Da